A member of a jewel heist crew is caught during a robbery & physical evidence shows he has unknown ties to Jane Doe. Someone from her past visits her but is unable to relay any useful information in time.
Patterson and her puzzle-expert boyfriend, David decode a tattoo clue that sends the team to the Centers for Disease Control (CDC). While at the CDC, the team discovers a hidden message on Jane's body that uncovers a plot that could have catastrophic global consequences. Meanwhile, Jane and Weller grow closer.
After a seemingly straightforward hostage situation turns out to have deeper international implications, the CIA and FBI find themselves racing against each other to apprehend the same criminal with a dark history. Carter expresses concern about Jane's trustworthiness, causing friction with Mayfair and testing Reade's loyalty to the team. Meeting Weller's family proves overwhelming for Jane as she grapples with her identity.
When an assassination leads the team to a dangerous app that allows criminals to track government vehicles, they have to work with the app's surprising creator to take it down. Jane and Weller attempt to keep their relationship professional. Zapata struggles with a moral issue.
One of Jane's tattoos sends the team to a remote location where they find themselves face to face with a dangerous criminal in a case that puts Jane and Weller's strained relationship to the test and threatens to expose Mayfair's secrets. Meanwhile, Patterson breaks the rules to solve a tattoo puzzle.
After a police officer is murdered, Patterson unlocks a disturbing tattoo that appears to have predicted his killing, and the team chases a violent clue trail to stop further attacks. Mayfair reveals secrets from her past to Weller, seriously testing their relationship.
Jane and Weller go undercover as a top-notch assassin couple in order to protect some lethal info. Meanwhile, David tries to repair his relationship with Patterson; and Carter and Mayfair disagree about how to deal with a menacing person.
Weller's team investigate an ex-soldier who starts killing people, even though he's supposed to be dead. Moreover, they find the same drug that was used to wipe out Jane's memory in his system. Jane looks for answers when seeing Oscar.
After a tip reveals a mole within the FBI, the team must hunt for the operative while facing extreme scrutiny from Inspector Fischer; The team's deepest secrets threatened to be exposed and everyone is a potential suspect.
After an armored truck is robbed, the team discovers that the stolen goods are chemical weapons and they must race to thwart a terrorist plot. Meanwhile, Jane grapples with a confusing memory of Weller - while growing even closer to Oscar.
After Patterson discovers a hidden message in the New York Times crossword, she embarks on a tattoo scavenger hunt that leads her into danger. Weller seeks his Dad's opinion about who kidnapped Taylor Shaw.
Rich Dotcom realizes he will never survive in prison, so he decides to give the FBI the option to capture Shohid Ahtar. The man who finances many of worlds terrorist organisations. But to get to him, the FBI needs to steal some paintings to lure him out.
A shooting takes place on a college campus while the team is investigating one of Jane's tattoos. The team halts their investigation to hunt for the shooter. Meanwhile someone from Mayfair's past resurfaces.