Genaro gets a job at a resort in hopes of marrying an American woman and moving to New York in search of a better life. He meets a tourist called Martha and everything seems going according to plan, until her boyfriend shows up.
After Yoli ends up alone again, she joins three other women in a fun weekend to get a break from their relationships with men. The husband and fiance of two of them join a private investigator to follow them in secret.
Three convicted criminals escape from prison carrying only a Güira, a Tambora and an Accordion. During their journey they meet with a bunch of interesting characters and are forced to use their musical skills to help them get home.