Following Elizabeth Keen's death, Reddington and the task force have disbanded, with Red's whereabouts unknown. But when one of their own is injured in the line of duty, they are drawn back together to bring down a global conspiracy.
The Task Force races to locate a Blacklister who uses any means necessary to return what has been unjustly stolen. Ressler asks Park for a favor. Cooper tries to piece together an event for which he has no memory.
Dembe's position as an FBI agent causes complication for Red as the task force handles a case involving military technology. Cooper and Park each find their personal lives increasingly complicated.
The death of a professional tennis player leads the Task Force to a doctor who may be fixing the odds for a major sports betting syndicate. Red digs deeper into Dembe's betrayal. Ressler struggles with sobriety.
A spate of coordinated attacks on Red's lieutenants puts Dembe in imminent danger, prompting him to relive the events that led him to join the FBI two years earlier.
The Task Force's investigation into Arcane Wireless, an untraceable cellular network for criminals, leads to unexpected consequences. Red races against the clock to get a colleague out of trouble.
An investigation into the Conglomerate, a group of former government-sponsored assassins, becomes complicated when the task force learns one of its own has ties to the group. Red digs deeper into the events leading to Liz's death.
The Task Force pursues the Chairman, who operates a dark web stock market trading shares of criminal organizations. Red takes extreme measures to locate a tracking device, causing Ressler to spiral. Cooper contacts with his blackmailer.
The task force is led to an unusual suspect when the clients of an escort service start turning up dead. Red and a friend try to recover an item after reuniting at a friend's memorial.
While searching for Senator Panabaker's missing daughter-in-law, the task force learns there may be a larger pattern of abductions. Red continues to piece together the mystery behind Liz's death.
Tensions rise when Cooper's search for his blackmailer overlaps with the Task Force's latest Blacklist case; Kennison admits to designing the tracking device which Liz ingested, but we so far do not learn how she came to do so.
Red chases a lead that could shed light on both Liz's death and Cooper's blackmailing. The task force experiences a major shake up when one of its own is arrested.