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| Episode cast overview, first billed only: | |||
| Tina Hobley | ... | Chrissie Williams | |
| Bob Barrett | ... | Sacha Levy | |
| Jimmy Akingbola | ... | Antoine Malick | |
 |
Michael Thomson | ... | Jonny Maconie |
| Rosie Marcel | ... | Jac Naylor | |
| Catherine Russell | ... | Serena Campbell | |
| Guy Henry | ... | Henrik Hanssen | |
|
|
Rob Ostlere | ... | Arthur Digby |
| Lauren Drummond | ... | Chantelle Lane | |
|
|
Paul Bradley | ... | Elliot Hope |
| Chizzy Akudolu | ... | Mo Effanga | |
| Hugh Quarshie | ... | Ric Griffin | |
|
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Jotham Annan | ... | Nathan Hargreave |
|
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Sandra Voe | ... | Adrienne McKinnie |
|
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Charlotte Randle | ... | Anna Patterson |
Jac returns from Japan after six weeks but the relationship between her and Jonny deteriorates almost immediately but a later incident brings them closer and Jac confesses her love for him. Malick's former college girlfriend, Anna Patterson, turns up in Holby complaining of stomach pains and also looking for their missing son Jake. A subsequent operation reveals cancer cells and a review that she has advanced bile duct cancer and secondary tumours on her liver. Ric advises her that she has weeks to live and tells Malick to make amends with his estranged son. Serena makes her feelings on her mothers care at Holby clear to Henrik. Written by Bridie
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