In her opening monologue, host Chelsea Handler, who is the only one from among her siblings who didn't attend college, records a commencement speech since many colleges have asked her to speak at their graduation ceremonies. Chelsea and her round table panelists Ben Gleib, Jen Kirkman and Ross Mathews discuss Corey Feldman placing a restraining order on his 300-pound female roommate, Chris Brown having an altercation at a Vegas nightclub, and 29-year old US Olympic athlete Lolo Jones coming out as a virgin as she is saving herself for whoever her husband. Chelsea presents an interview she did with her gay book agent Michael Broussard following her niece's recent bat mitzvah. And Chelsea's guest, animal expert Donald Schultz, presents some baby animals for Chelsea to pet. They also discuss his upcoming show, Animal Intervention (2012), which presents pets being rescued, among them exotic animals that never should have been pets in the first place.