When May gets kidnapped, Hydra sends out an impersonator to lure Coulson into a trap. Fitz tries to find the confidence to join the rest of the team in their social activities.
The world turns against S.H.I.E.L.D. when Hydra impersonates them to attack The United Nations, and an unexpected enemy leads the charge to bring about their downfall.
A mysterious man is killing off former S.H.I.E.L.D. agents and carving the same markings as Coulson. Coulson tries to track him down. Meanwhile, May leads a team on a manhunt for Ward.
Coulson and team find themselves in an epic face-off against Hydra to uncover an ancient secret, while Ward kidnaps his brother, Senator Christian Ward, for a violent trip down memory lane.
While Coulson's team tries to find the entrance to the mysterious alien city, the rest of the agents try to rescue Raina when they find out that Hydra is after her.
Cal wants vengeance, so he rallies a team of super villains to crush S.H.I.E.L.D. Meanwhile, May turns to her ex-husband, Dr. Andrew Garner, to help with a crisis threatening the harmony of the team.
The team are bewildered by a recent shocking revelation as they face a difficult decision. Meanwhile, Bobbi and Mack declare their loyalty to Hunter; and Ward and Agent 33 take care of a private matter.
War comes to Coulson's doorstep in a way he never anticipated as shocking revelations are brought to light, and Skye struggles to control her new abilities but will soon make a decision that irrevocably changes her life.
As Robert Gonzalez makes his move, Coulson must do whatever it takes to protect the future of S.H.I.E.L.D. Meanwhile Skye's journey to control her powers take a surprising turn when she meets the enigmatic Inhuman named Lincoln.
The story of Melinda May's transformation into "The Cavalry" is revealed as she finds herself at a crossroads in the war between Coulson and Gonzales. As Skye learns more about her true heritage from Lincoln, the truth about Inhumans will send her in a new direction.
A dangerous new alliance is formed as Coulson and Hunter turn to the last person anyone would expect, Grant Ward! As the war between S.H.I.E.L.D. factions continues, Skye and Lincoln will find themselves drawn into this conflict.
Gonzales and Coulson must find a way to put their differences aside and work together against HYDRA, even if it means teaming up with someone they don't trust.
S.H.I.E.L.D puts everything on the line to survive a war that blurs the line between friend and foe. Coulson and his team will be forced to make shocking sacrifices that will leave their relationships and their world changed forever.
