NYC is infected! Even though the lizard/Dr. Curt Connors is in jail the game takes place after the events of the movie when different cross-species are created at OsCorp but when they break free OsCorp hires Allistair Smythe to invent robots to kill the cross-species and infected people Enemies in the game are Rhino, Scorpion, Black Cat, Allistaire Smythe and The lizard has a small cameo appearance.
Did You Know?
[when approaching the shocked Spider-Man from behind him
Come on, Itsy-Bitsy Spider, let's play!