In her opening monologue, host Chelsea Handler talks about students from Liberty University who have created a series of videos to spread the word about celibacy before marriage, and how it relates to the staff on her show. Chelsea and her round table panelists Bobby Lee, Sarah Colonna and Gary Valentine discuss Gary's premature death, both Britney Spears and Janet Jackson vying to be a judge on The X Factor (2011), Katy Perry's song lyrics expressing her anger over her recent divorce, a Florida man claiming to be half orangutan, and a recent survey where 15% of the population admitted to having sex while driving. Brad Wollack makes a plea on behalf of Jennifer Aniston. Chelsea chats with guest Tyler Perry about his new movie Good Deeds (2012), how the movie storyline matches his own life, working with Kim Kardashian West, and his friendship with Oprah Winfrey. And Chelsea's posse gives her a special birthday present.