Mindy heads to Stanford University, where she makes a less-than-stellar first impression in her fellowship class. Meanwhile, back in New York, the practice is determined to win a basketball tournament.
While trying to make friends in her new city, Mindy runs into a nerd-turned-billionaire ex-flame from Princeton. She imagines the life of riches she could have had with him and questions her relationship with Danny. Meanwhile, back in New York, Danny and Morgan think they witness Lauren cheating on Jeremy with Peter, so they devise a way to spy on Peter.
Rob gives Mindy an opportunity to start up her own practice in San Francisco, and she struggles to tell Danny, especially when Danny shows her the brownstone he bought for the two of them in New York. Meanwhile, Jeremy and Peter grapple with the fact that Lauren is moving to Texas and leaving them both behind.
Mindy has some big news to tell Danny, but just as she is getting ready to tell him, his father and half-sister show up for an unexpected visit. The whole crew is invited to Annette's house for the world's most awkward family dinner.
Mindy has made up her mind to move to San Francisco and start a practice with Rob, but her credit history jeopardizes their ability to get a loan. Meanwhile, Danny tries to let the office know that he is moving to San Francisco with Mindy, but they're convinced his "big news" is something completely different.
Danny is upset with Mindy's horrible eating habits and decides to make a deal with her that he will stop smoking if she stops eating poorly. Meanwhile, Jeremy struggles to fill Peter's spot at the practice.
Mindy's fertility clinic opens, but with zero track record in the fertility field, attracting new patients is tougher than she imagined. Meanwhile, at Shulman and Associates, the nurses try to raise money for obese nurses while trying to get to know Dr. Bergdahl.
When Danny's priest dies after hearing Danny's confession, he frantically tries to find a new priest so he can atone for his sins. Meanwhile, Jeremy tries to force the practice to attend his one-man show.
Mindy struggles with her body image as her baby bump begins to show, so she agrees to meet with Sheena, an aspiring personal stylist. Meanwhile, Jeremy, heartbroken over Lauren, tries to dive back into the dating pool, and unexpectedly runs into Morgan's girlfriend, Jessica.
Mindy starts to question Danny's commitment to their relationship when he's a no-show for dinner with her parents. Meanwhile, when Morgan thinks he overhears Mindy saying Danny is not the father of her baby, he gathers all the guys with whom she's ever slept, in an attempt to figure out who is the real father.
Mindy becomes convinced that she must get Leo into the best preschool in Manhattan. However, with Danny out of town, she must enlist the help of her work nemesis, Jody, to impress the admissions committee.