Mindy is a 30 something Ob/Gyn whose love life hits a snag after a messy break up with her long term boyfriend. After getting drunk and making a scene at his wedding, Mindy vows to put the past behind her, find the perfect man and get her life on track.
Mindy spends Thanksgiving at Gwen's house, where she runs into her former blind date Dennis and his new girlfriend. Elsehwere, Jeremy is introduced to Betsy's family, and Danny spends the evening alone at the hospital.
When Mindy encourages a teenager in her building to take things slow with her boyfriend, she is forced to reflect on her own relationship with Josh. Meanwhile Danny becomes concerned after receiving an anonymous complaint.
To put some distance between Jamie and Lucy, Mindy sets up Lucy on a Valentine's Day date with Danny, who is suffering from insomnia after his breakup with Jillian. Meanwhile, Morgan turns to Jeremy for advice on how to pick up women.
Mindy accidentally hooks up with a male prostitute, and tries to help him with his dream to become a singer. Danny and Alex's small gathering turns into a party when Mindy finds out Danny did not want to invite her.
During a trip to Santa Fe for a medical conference, Mindy visits her ex-boyfriend Josh, who wants to make amends for his deceit. Jeremy and Morgan clash while preparing for the conference. Danny receives a shock when his ex-wife shows up at the hospital.