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The greatest tragedy in the history of Mexico marked the lives of 49 families who lost their children in a fire in the ABC nursery, and of an entire nation. In the wake of the tragedy, the parents of the deceased and injured children seek to rebuild their lives while demanding justice. ABC Never Again brings us the story of two families that took refuge in love to overcome their loss, and while they try to have children again, depression and age threaten their hopes. The search for happiness joins the fight to bring justice to those responsible for a tragedy that the entire country mourned in a case that is riddled with corruption, negligence, and abuse of power that involves influential politicians and wealthy Mexican families.