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Title: In Case of (Re)Birth (13 Jan 2012)
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| Episode cast overview, first billed only: | |||
| Patrick Wilson | ... | Dr. Michael Holt | |
| Jennifer Ehle | ... | Anna Paul | |
| Margo Martindale | ... | Rita Perkins-Hall | |
| Pablo Schreiber | ... | Anton Little Creek | |
| Rachelle Lefevre | ... | Dr. Kate Sykora | |
| Leland Orser | ... | Charlie Reinhart | |
| Eriq La Salle | ... | Evan 'E-Mo' Morris | |
| Rhys Coiro | ... | Dr. Zeke Barnes | |
| Dana Wheeler-Nicholson | ... | Jayne Reinhart | |
| Afton Williamson | ... | Autumn | |
| Britt Lower | ... | Nina | |
| Julie Benz | ... | Christina Holt | |
| Adrian Martinez | ... | Hector | |
 |
Kailani Coba | ... | Maribel Lopez |
| Tijuana Ricks | ... | Nurse Charisse | |
Michael and E-Mo disagree about how to treat a patient with a brain tumor. Meanwhile, a teenage girl gives birth at the clinic and immediately runs out, leaving the baby behind.
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