All the Mystic Warlords of Ka'a cards mentioned in this episode have never been mentioned before. This is a running joke throughout the series, mocking the ridiculous complexity of the game, but this is the first time the characters start to realize this.
Amy expresses her contempt for comic books to Sheldon, saying they are "lame-o". However the actress who plays her, Mayim Bialik, has been quoted as saying she was raised on comic books and loves science fiction.
The title comes from one of the cards in the Wild West and Witches expansion pack from the Mystic Warlords of Ka'a the guys are playing, the Flaming Spittoon card. It was a card played by Sheldon, who, enthusiastic with the inaugural card game, wore a white cowboy's hat, a pair of boots and spurs, and even spat into the spittoon to symbolize the card.