Leonardo and friends have to help survivors escape the city. Vanessa must help the Signori decide the fate of Florence. Pope Sixtus continues to raise an army for his Crusade. Clarice continues her search for Carlo.
Riario fights his own inner demons. Leonardo is struggling with his conciousness - is he an enlightened inventor or just an inventor of weapons of mass destruction? Lucrezia has found out the inconvenient truth about her former ally.