Living in a small village, Megumi's two main interests are classmate Natsuno Yuuki and a European-style house on a hill. One day, when her fascination with the house leads her to climb the hill, she vanishes.
No one in Sotoba - the village surrounded by death - is safe, as a frustrated Toshio fails to find a cure for the epidemic strangling his town. Convinced that Megumi has risen from the dead, Natsuno researches darker sources.
Toshio leads those who haven't joined the Shiki - or fled the village - on a raging, blood-soaked hunt, but there's still one place they haven't looked. As the vampires strike back, Seishin continues his watch over Sunako.
Motoko's concerns for her father-in-law's health are brushed off as exaggerated worry, but soon her husband and children fall victim to the Shiki's curse. Wandering the bloodied streets alone amidst the panic, the shaken widow calculates her revenge.