X-Men, still grieving over the death of Phoenix (Jean Grey), are investigating a case of a missing mutant girl in Northern Japan. This leads them to a mysterious virus that turns mutants into monsters. U-Men and the Inner Circle want it.
Logan is asked by his old friend, a cop from Japan, to help him take down Shingen Yashida's crime syndicate and save Mariko, Logan's lost love, from forced marriage arranged by her father Shingen. Yukio, a female assassin, helps him.
Just as teenage mutant Kitty Pryde is welcomed to the X-Men, the team of mutant heroes are called into battle to prevent Magneto and his Brotherhood of Evil Mutants from crashing a comet into the Earth.
Legendary half-vampire, half-human vampire hunter Blade is tracking Deacon Frost, a very powerful and influential vampire who killed his mother and who heads Existence, a secretive vampire organization that operates in Southeast Asia.
Black Panther is the ruler and protector of the African nation of Wakanda. Using technology, wits, and extraordinary fighting ability he must protect his nation from an invasion led by Ulysses Klaw, the man who killed his father.
After an explosion at the school, the X-Men went their separate ways. But they must unite once again under the leadership of Wolverine to prevent an inevitable war while also dealing with present problems.