First off, wow do those action sequences look good. The action isn't the only thing to be excited about, however, as it looks like for the first time ever a Spider-Man game will let you travel around as Peter Parker? That's not a 100% thing, but it did look like there were some sequences featuring the player controlling Parker, and maybe even Mj.
We also saw alternate Spider-Man Miles Morales get introduced, so we're hoping for some action with him involved! As for other familiar faces we see Aunt May, Wilson Fisk (Kingpin) heading to prison, Norman Osborn (Green Goblin) running for mayor, and a new villain, Mr. Negative, looking to destroy New York.