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Director Denis Villeneuve noted that he was fully aware of the immense pressure he was under, and how hardcore fans of Blade Runner (1982) view the prospect of a new movie: "I know that every single fan will walk into the theater with a baseball bat. I'm aware of that and I respect that, and it's okay with me because it's art. Art is risk, and I have to take risks. It's gonna be the biggest risk of my life but I'm okay with that. For me it's very exciting. It's just so inspiring, I'm so inspired. I've been dreaming to do sci-fi since I was ten years old, and I said 'no' to a lot of sequels. I couldn't say 'no' to [this film]. I love it too much, so I said, 'Alright, I will do it and give everything I have to make it great'."
The first letter of the names of each of the wooden animals that Rick Deckard carved in this movie: Rhino, Antelope, Cat, Horse, Elephant, Lion, spell "RACHEL".
To make Joi (Ana de Armas) appear more artificial, editor Joe Walker experimented by freezing her image for nine frames just before she responds to a question. That way it looked like her program paused for a split second, as if her processor was briefly occupied in coming up with an answer. However, it felt corny and it was decided that her artificiality was already convincingly communicated through her fast costume changes and transparency.
David Bowie was director Denis Villeneuve's first choice for the role of Niander Wallace, but he died six months before the start of shooting. Jared Leto was cast instead because of his "similar rock star vibe," since he fronts the rock band Thirty Seconds to Mars.
As seen in this movie, the baseline test that "K" must recite back ("A system of cells interlinked within / Cells interlinked within cells interlinked") was Ryan Gosling's idea. He employed an acting technique called "dropping in", which induced a trance-like and hypnotic effect on his performance.
The giant Joi in the hologram advertisement was supposed to be her "default" setting, the idea being that "K" customized her voice and appearance to a less sexualized version. The advertisement version of Joi was not voiced by Ana de Armas, but first assistant editor Mary Lukasiewicz. She recorded a temporary voice-over, but the producers decided to keep it in the finished movie.
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