After Megamind became the hero of Metro City, Minion told him that a group of villains known as the Doom Syndicate took Metro Man and Megamind's DNA. Megamind must defeat them and save Metro City.
Did You Know?
The game features a team of supervillians called the "Doom Syndicate". They were supposed to appear in the film to be Metro Man's other job while Megamind was on the low, but the idea was scrapped, as it would've created more plot lines than necessary. See more
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Spun-off from Megamind