When the Friendship Map grows bigger to reflect the world beyond Equestria, the Mane Six realize they'll need a way to spread the message of friendship far and wide. Luckily, Twilight knows just what to do - open a School of Friendship.
Pinkie Pie develops a new hobby of playing an annoying musical instrument that is popular in Yakyakistan, but every pony in Ponyville is annoyed by it. When her friends tell her to stop playing because she isn't good, she loses her happiness, and now her friends have to try to cheer her up and get her back to normal again.
When Twilight discovers there's another school of friendship, she and Rarity go to investigate and are shocked to discover that Twilight's idol and Pillar of Old Equestria, Starswirl the Bearded, is enrolled at Friendship U.
When Trixie is invited to bring her magic show to the far-off land of Saddle Arabia, she can think of nopony better to bring along than her great and powerful assistant, Starlight-but, not all friends are meant to travel together.
Fluttershy and Applejack journey to the edge of the map on a Friendship Quest to help a group of ponies named Kirin who are so afraid of hurting each other's feelings, they've taken a portion of silence.