| Credited cast, sorted by IMDb STARmeter: | |||
| Vin Diesel | |||
| Zoe Saldana | ... | Neytiri | |
| Kate Winslet | ... | Ronal | |
| Stephen Lang | ... | Miles Quaritch | |
| Jemaine Clement | ... | Dr. Ian Garvin | |
| Sigourney Weaver | ... | Dr. Grace Augustine | |
| David Thewlis | ... | Peylak | |
| Chloe Coleman | ... | Young Lo'ak | |
| Michelle Yeoh | ... | Dr. Karina Mogue | |
| Sam Worthington | ... | Jake Sully | |
| Cliff Curtis | ... | Tonowari | |
| Giovanni Ribisi | ... | Parker Selfridge | |
| Oona Chaplin | ... | Varang | |
| Edie Falco | ... | General Ardmore | |
| Joel David Moore | ... | Norm Spellman | |
A sequel to Avatar (2009).