Balthazar meets Dean and Sam and tells that Raphael and the other angels are hunting them down and he sends the brothers to an alternate Vancouver in a parallel universe. The Winchester brothers learn that in this Vancouver, they are actors of a TV show called "Supernatural" and Sam is married with Ruby, actually the actress Genevieve Nicole Cortese Padalecki. When they make a spell to return to their universe, they also discover that magic does not work in this universe.
Raphael launches an attack on Castiel and his allies, sending a particularly frightening angelic hitman after Balthazar, Sam and Dean. In an effort to protect the brothers, Balthazar sends them to an alternate universe where they are the stars of a TV show called "Supernatural" and they are actors named "Jensen Ackles" and "Jared Padalecki." The brothers are confused when Castiel appears to be a tweet-happy actor named Misha Collins and Sam is married to Ruby.
To protect Sam and Dean from a surprise attack from Raphael, Balthazar sends them both into an alternate universe where their lives are a TV show called Supernatural (2005).
- Dean and Sam are doing research at Bobbys House when Balthazar appears. He says that Raphael is aiming to kill all of Castiels allies and affiliates so he gives them a key and sends them to an alternate reality to keep them out of harm's way. Supposedly, the key opens a door where he has stored the stolen Angelic Weapons of Heaven, which will help Castiel to retain control in Heaven.
When they appear in the alternate reality, Sam and Dean find themselves on the set of "Supernatural"- a show that appears to be about their lives and where everyone mistakes them for the actors Jensen Ackles and Jared Padalecki. They try to contact Castiel, but instead encounter Misha Collins, who plays Castiel on the TV Show. Taking refuge in Jensen's luxurious trailer, they do some research about Jensen and Jared, and Dean is horrified to learn that Jensen was on Days of Our Lives. Dean suggests they try doing the same spell Balthazar did in order to get them back to their own reality.
Discouraged that there are no 'real' saints' bones or other items they need on the set of Bobbys house, Sam and Dean have the actors' driver, Clif Kosterman, take them to Jared's place, which turns out to be a large ostentatious mansion with a tanning bed in the living room and an alpaca in the backyard. Sam and Dean are shocked when Ruby - or rather the actress who plays her - appears and kisses Sam, who she believes to be her husband, Jared. After Genevieve Padalecki heads out to a charity function for the International Otter Adoption Fund, Sam and Dean go online and purchase some saints' bones for rush delivery using Jared's credit cards (they max out at least one). Dean then spends the night on Jared's couch, while Sam alternates between surfing the internet for signs of the supernatural activity and sleeping with Genevieve.
The next morning, Clif drives them to the airport to pick up the rush delivery before taking them back to the set. They have to try and act in a scene which ends badly after many takes, but in between takes, they try and do the spell. When nothing happens, they come to the conclusion that in this reality there is no real supernatural, no magic.
Back on set, the angel hitman Virgil appears and tries to vanquish Dean with his angel powers. He, too, is devoid of powers in this reality, so Sam and Dean are able to take him in a fight and start pummeling him on the set of the Dragon's hideout from Like A Virgin. The rest of the crew intervenes, however, and during the resulting scuffle Virgil pickpockets the key Balthazar gave Sam before running away.
The crew of the show is now suspicious because "Jared" and "Jensen" are behaving out of character. Normally they don't speak to each other, they came in with a mysterious package (the saint's bones) which the crew believes are either drugs or black market organs, and now they've beaten up Virgil, who everyone believes to be an extra. Director Bobby Singer calls showrunner Sera Gamble and suggests that they get Eric Kripke to come to Vancouver and talk to them. Sera reluctantly agrees, although Kripke is sequestered in a cabin writing the script for "Octocobra." Meanwhile, Virgil takes Misha hostage and kills him so he can use his blood to contact Raphael.
Bob confronts Sam and Dean, and they drop the pretense of being Jared and Jensen and tell him that they quit. Dean says that at least in their world they make a difference. They then go back to Jared's house and learn from Genevieve that Misha is dead, so they go to the scene. A witness states that the killer was speaking to "Raphael," and they learn from the relayed conversation that Virgil is trying to get back to their reality. While they wait for him on the set, Dean suggests to Sam that maybe if they get stuck in this reality, Sam's life would be better. But Sam disagrees because back in their world they do matter, and he doesn't like that in this world they aren't even brothers.
Virgil returns on set just as Kripke arrives to speak to them, and the angel goes on a killing spree, killing Eric Kripke, Bob Singer, Kevin Parks, and Lou Bollo before Sam and Dean manage to knock him out and get the key. Just as Sam has the key in hand, Raphael activates the nearby gate between the worlds, and they land back in their own reality.
Raphael - now in a female vessel -demands the key, but Balthazar arrives and reveals that the key and Sam and Dean's journey was all a ruse to distract Raphael. She threatens them, but Castiel arrives and reveals that he now has all the Angelic Weapons. He threatens to kill Raphael, and she leaves. Castiel then returns Sam and Dean to Bobby's house, promising to reveal more of what is happening in Heaven soon. Back at home, Sam and Dean reflect that they are now back in their old, crummy house with no money, but at least they're talking to each other.