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Title: I Guess This Is Goodbye (16 May 2010)
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| Episode cast overview, first billed only: | |||
| Teri Hatcher | ... | Susan Delfino | |
| Felicity Huffman | ... | Lynette Scavo | |
| Marcia Cross | ... | Bree Hodge | |
| Eva Longoria | ... | Gabrielle Solis (as Eva Longoria Parker) | |
| Ricardo Chavira | ... | Carlos Solis (as Ricardo Antonio Chavira) (credit only) | |
| Doug Savant | ... | Tom Scavo | |
| Kyle MacLachlan | ... | Orson Hodge | |
| Dana Delany | ... | Katherine Mayfair (credit only) | |
| Drea de Matteo | ... | Angie Bolen | |
| Maiara Walsh | ... | Ana Solis (credit only) | |
| Brenda Strong | ... | Mary Alice Young (voice) | |
| James Denton | ... | Mike Delfino | |
| Kathryn Joosten | ... | Karen McCluskey | |
| Jeffrey Nordling | ... | Nick Bolen | |
| Beau Mirchoff | ... | Danny Bolen | |
Gabrielle risks her safety to help Angie; Lynette and her baby's fate lie in Eddie's hands; Susan comes to grips with financial woes; Bree considers confessing a secret; Angie must submit to Patrick's demands to protect Danny. Written by ABC Publicity
