| Episode cast overview, first billed only: | |||
| Blake Lively | ... | Serena van der Woodsen | |
| Leighton Meester | ... | Blair Waldorf | |
| Penn Badgley | ... | Dan Humphrey | |
| Chace Crawford | ... | Nate Archibald | |
| Taylor Momsen | ... | Jenny Humphrey | |
| Ed Westwick | ... | Chuck Bass | |
| Jessica Szohr | ... | Vanessa Abrams (credit only) | |
| Kelly Rutherford | ... | Lily van der Woodsen | |
| Matthew Settle | ... | Rufus Humphrey | |
| Margaret Colin | ... | Eleanor Waldorf | |
| Connor Paolo | ... | Eric van der Woodsen | |
| Wallace Shawn | ... | Cyrus Rose | |
| Zuzanna Szadkowski | ... | Dorota Kishlovsky | |
| Michelle Trachtenberg | ... | Georgina Sparks | |
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Ben Yannette | ... | Cameron |
Blair must decide whether to meet Chuck at the top of the Empire State Building or risk losing their future together. A Gossip Girl gossip bomb involving Dan explodes Serena and Nate's relationship. Dorota and Vanya welcome their baby. Jenny hits rock bottom. Georgina returns to the Upper East Side...and she has an agenda. Written by CW Publicity