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| Episode cast overview, first billed only: | |||
| Edie Falco | ... | Jackie Peyton | |
| Eve Best | ... | Dr. Eleanor O'Hara | |
| Merritt Wever | ... | Zoey Barkow | |
| Paul Schulze | ... | Eddie Walzer | |
| Dominic Fumusa | ... | Kevin Peyton | |
| Anna Deavere Smith | ... | Gloria Akalitus | |
| Peter Facinelli | ... | Dr. Fitch Cooper | |
| Ruby Jerins | ... | Grace Peyton | |
| Mackenzie Aladjem | ... | Fiona Peyton | |
| Stephen Wallem | ... | Thor Lundgren | |
| Arjun Gupta | ... | Sam | |
| Michael Buscemi | ... | God | |
| Deidre Goodwin | ... | Brooke | |
| Pedro Pascal | ... | Steve | |
| Jolly Abraham | ... | CF Lab Tech | |
Dr. O'Hara shows up at work still high on the Ecstasy she took the night before. Jackie deals with a young boy who may have a serious respiratory problem. His parents are thrilled when Jackie says they can do the necessary tests at All Saints but may have sent them home too early. Having recovered from his suicide attempt, Eddie visits Jackie's husband Kevin at the bar. Nurse Sam begins to ask if either Jackie or Dr. O'Hara have a drug problem. Dr. Cooper has taken to twittering and it's driving Jackie crazy. Written by garykmcd
