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Jane Levy played the role of Mandy Milkovich in season one, but was then re-cast with Emma Greenwell, when Levy took a leading role in ABC's Suburgatory (2011).
Unusual for a television show, creator John Wells has a very strict policy of no scripts allowed on-set. The actors and actresses have to know their lines by heart.
John Wells warned writers and actors that this was not a "redemption" story and that while there would be some positive storylines, that they should look elsewhere if they wanted to work on something more uplifting and positive.
Steve Howey, who plays Kev, spent the entirety of season three recovering from a torn Achilles' tendon.
With the renewal for season 11, it became the longest show in both episodes (134) and seasons of all of Showtime's history.
A unique show trademark is the main character breaking the fourth wall at the episodes' beginnings, inquiring as to why the viewer supposedly did not view the previous episode, before recap flashbacks are shown (with unaired scenes).