The show was originally supposed to take place in a type of shopping centre with each of the Misfits working in a different shop on Saturdays. It was changed to the show as it is now known after E4 told Howard Overman to make it more "urban".
Antonia Thomas was originally reluctant to take the role of Alisha Daniels due to the heavy amount of sexual activity involved in the part. However, she changed her mind when she read the script further, met with Howard Overman and found that the character had far more depth than originally thought. Thomas also joked in an interview that when Howard Overman met with her and asked if there were any requests for character development in Series 2 she answered "less inappropriate sexual things to do on screen."
Joseph Gilgun's character Rudy Wade was brought in after Robert Sheehan (Nathan)'s departure after Series 2. However, Howard Overman decided he didn't want another Nathan, so decided to make Rudy 'more emotional' which is present in the character's power of emotional induced multiplication.
Karla Crome and Nathan McMullen both auditioned for other characters before being chosen to play Jess and Finn respectively. Crome originally auditioned for Curtis' love interest Nikki and McMullen, a minor villain in Series 3.
Joseph Gilgun got '23456' tattooed on to his chest in honor of his time on the series. Each number represents a different cast member from Series 3, including Matthew McNulty whose character of Seth was becoming a regular.
Over the course of the show's first three seasons, each character was given their own Twitter accounts, supervised by writer Howard Overman himself. Initially used for Viral Marketing, these accounts were also used to provide extra information about each character and were key to the 'Guy in the Mask' arc during the show's second series. They also bridged gaps between series' building up to the Misfits: Vegas, Baby! (2011) and Misfits: Erazer (2011) spin-off short films.
Season Four has the least cast members at anytime (4 in episodes 1 and 5 with only 3 credited in the latter), while also has the most altogether (6 counting Matt Stokoe (Alex)). With the exception of episode 5, only up to 4 cast members are featured in the opening titles.
The trivia items below may give away important plot points.
The powers attained after the storm represent flaws within the characters. In season 1, Alisha (Antonia Thomas), who has casual sex without regard to others, is given the power of hyper-sexual arousal. Curtis (Nathan Stewart-Jarrett), who constantly regrets his failed athletic career, can now reverse time. Kelly (nm2282610), conscientious of how people saw her, has the ability to read others' minds. Simon (Iwan Rheon), an introvert can now become invisible. Nathan (Robert Sheehan) had a "live for today" attitude and so becomes immortal.
Iwan Rheon (Simon), as with most of the other cast, were disappointed with their power change in Series 3. Antonia Thomas (Alisha), however, stated that she was not disappointed with the change because "her old power was shit".
"This could be the start of something huge. I can feel it in me nutsack." - The final ever words spoken on the show, delivered by Rudy (Joseph Gilgun), as the gang debate whether or not to become real superheroes.