The role of Jacques was supposed to be played by Jean-Claude Van Damme up until a week before shooting began. Gunn said "the guy was kind of A.W.O.L. I just couldn't risk that personality type on this movie." Kevin Bacon stepped in as a last minute replacement.
Rainn Wilson came to the project via Jenna Fischer's relationship with her ex-husband James Gunn. Gunn was discussing his script with Fischer and asked her to take a look at it, sending her a copy on the set of The Office (2005). Fischer read the script, loved it and thought Wilson would be a great choice as the lead. She gave the script to her co-worker, and Wilson immediately decided to make the film.
Towards the end of the movie, when Liv Tyler is in her rehab group session, she is heard stating "f**ked up, insecure, neurotic, and emotional". This is a reference and nod to her rocker father Steven Tyler (of Aerosmith) and his 1980's song "FINE" which is an acronym for the same line.
James Gunn originally wanted John C. Reilly to star, but he wasn't thought to be a big enough name. But, John C. Reilly appears in Guardians of the Galaxy(2014) directed by James Gunn and costars Gregg Henry, Sean Gunn, Michael Rooker and Nathan Fillion.
Libby, a.k.a. Boltie (Ellen Page) uses metal claws like Wolverine. Page played Kitty Pryde in X-Men: The Last Stand (2006) and X-Men: Days of Future Past (2014). At one point in the comics, and during the alternate reality of the Age of Apocalypse, Kitty Pryde uses metal claws as part of her costume, just as Boltie does.
Guy in the rehab group said he needed to go back to K.I.S.S. (Keep It Simple Stupid). This was what Rainn Wilson's character Dwight in The Office (2005) said was Michael's best advice, which hurt his feelings every time, in the episode "Initiation".