| Episode cast overview, first billed only: | |||
| Jack Coleman | ... | Noah Bennet | |
| Robert Knepper | ... | Samuel Sullivan | |
| James Kyson | ... | Ando Masahashi (as James Kyson Lee) | |
| Masi Oka | ... | Hiro Nakamura | |
| Hayden Panettiere | ... | Claire Bennet | |
| Zachary Quinto | ... | Sylar | |
| Sendhil Ramamurthy | ... | Mohinder Suresh | |
| Madeline Zima | ... | Gretchen Berg | |
| Dawn Olivieri | ... | Lydia | |
| Elizabeth Lackey | ... | Janice Parkman (as Lisa Lackey) | |
| Kate Vernon | ... | Vanessa Wheeler | |
| Tamlyn Tomita | ... | Ishi Nakamura | |
| Danielle Savre | ... | Jackie Wilcox | |
| Sasha Pieterse | ... | Amanda Strazzulla | |
| David Anders | ... | Adam Monroe | |
Hiro's life hangs in the balance as his brain tumor worsens, prompting him to subconsciously deal with some of his past decisions. Meanwhile, Sylar pays Claire an unexpected visit to get answers as to why he isn't quite himself. Elsewhere, Samuel's plan to impress his long-lost love, Vanessa, takes a terrifying turn. Written by NBC Publicity