At the end of the fight scene in the bar, the waitress looks at Bob(Dwayne Johnson) and says "I hope he's catholic." The waitress is played by Meghan Park who stared in the Secret Life of The American Teenager which was a show about a catholic girl waiting until marriage to have sex.
Calvin cons the airport security guard with a story about a woman who cuts off her husband's penis, drives off with it, then throws it out of the window. This is a reference to a 1993 incident that made national headlines regarding Lorena Bobbitt cutting off the penis of her husband John Wayne Bobbitt.
The project was green-lighted by Universal Pictures in 2010 and Ed Helms and Will Ferrell were originally attached to star, but plans fell through and Universal stopped production. New Line Cinema got involved when Rawson Marshall Thurber convinced them to buy the script from Universal and the studio became the new domestic distributor through Warner Bros., while Universal handled overseas distribution.
Towards the end of the movie, Calvin asks agent Harris how will he contact her if he needs to talk to her. Agent Harris replies "just pick up the phone - we're always listening". Amy Ryan also starred in the The Wire as part of a team of police officers who used phone tapping to bring down drug dealers.
The trivia items below may give away important plot points.
The ending scene is an homage to Sixteen Candles (1984) with Johnson's character wearing nearly the same outfit as the character Jake Ryan Michael Schoeffling in the movie, one hand in pocket, other hand waving hello, and leaning against a red vehicle.