प्लॉट

Larry attempts a preemptive breakup with an ailing Loretta, and learns with Jeff that you can't make an "empty gesture" to a Funkhouser.

While an ailing Loretta (Vivica A. Fox) awaits biopsy results, Larry (Larry David), unhappy in the relationship, realizes if he wants to end things with her, he needs to do it before she gets her diagnosis. Loretta is never happy, no matter what Larry does for her, including bringing her meals in bed. Larry is still living with Auntie Rae (Ellia English), Leon (J.B. Smoove), Daryl (Nick Nervies) & Keysha (Carla Jeffery).

Larry tells Jeff he has to break up with Loretta before she is diagnosed with cancer. Jeff & Susie (Susie Essman) invite Larry to their dinner party that night. When Larry asks about who is invited, Susie refuses to share the guest list. Larry is angry at the doctor Shafer, who has come to the house to see Loretta, as picks a minute maid out of Larry's refrigerator, without his permission. Shafer is angry that Larry did not offer him a beverage even after he visited personally to see Loretta. Marty Funkhauser (Bob Einstein) backs Dr Shafer and says liquids are fair game. Larry mentions that he will see Marty at Susie's party. Marty was not invited to the party and is angry at Larry for telling him.

Meanwhile, Funkhouser's sister Bam Bam (Catherine O'Hara) has been released from the mental institution, and when Larry and Jeff (Jeff Garlin) pay a visit (Marty has forced them to spend time with Bam Bam), their attempted "empty gesture" gets complicated when Jeff ends up sleeping with her. Larry goes to the bathroom and stops in the kitchen to make himself a sandwich. He returns to the living room to find Bam Bam and Jeff gone and realizes they are upstairs having sex.

The Greene's host a dinner party that goes awry. Marty complained to Susie (Susie Essman) and ended up at the party with Bam Bam. Larry is surprised to see Dr Shafer at the party & is offended that he wasn't told that Shafer was coming. Larry is also surprised to know that Shafer is gay & offends Shafer by suggesting that he doesn't look gay. Marty is very happy that after Jeff & Larry's visit Bam Bam seems to be a completely different person and is in very high spirits. Bam Bam announces to the guests that she had sex with Jeff - and Jeff defends himself by insisting she's crazy. Susie eventually agrees that even Bam Bam is not crazy enough to sleep with Jeff. Marty decides to take Bam Bam to the mental institution.

Larry runs into Cheryl (Cheryl Hines) at a restaurant where he went to pick up some dinner, and they admit they miss each other. Cheryl says that she didn't like the phase where Larry was always at home. She liked him better when he was working on Seinfeld the whole time. Larry's visit is cut short when he has to race home to try and beat the doctor who has Loretta's results. He is delayed when Bam Bam stops him outside the house. Together, Bam Bam and Larry witness a robbery in their neighborhood. The police arrive and asks Larry to record his statement. Eventually, Larry arrives too late - it looks like Larry's in for the long haul, when Dr Shafer says that Larry will have to put his life on hold for 4 years to get Loretta back on track. On top Loretta is going to lose hair, gain weight and so on.. she will require a lot of medicines, a lot of vitamins, and organic juices 3 times a day.