The action icon - dubbed the 'Muscles from Brussels' - is back on the big screen in Pound of Flesh as retired black-ops agent Deacon.
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After Deacon becomes the victim of an organ theft while trying to donate a kidney to his dying niece, he swears revenge at all costs.
Deacon sets out on a mission of death across China to retrieve his stolen body part from the criminals who took it.
Pound of Flesh reunites Van Damme with Assassination Games and Six Bullets director Ernie Barbarash.
The movie will open in the Us on May 15, and is due for a UK Blu-ray and DVD release on June 22.