It's not easy to find the perfect girl, even when you're the same sex! Kanako thought attending an all-girls school would be the perfect way to meet the girl of her dreams, but after her hot new roommate turns out to be a guy in drag, and catching the eye of the most popular girl in school only brings down the wrath of all the OTHER similarly obsessed girls, she's not so sure! Complicate things with a cat-eared dorm leader, her roommate's rude-mannered maid, an identical twin sister (who attends an all-boys school of course) and WAY too many attractive girls of questionable persuasions and the question becomes whether Kanako will die from frustrated nosebleeds! (Life would be SO much easier if guys didn't literally give her the hives!) Will Kanako ever find a non-polar opposite of a compatible non-opposing polarity? Let's just say that the quest for true love will not run straight in Maria Holic.