Trama

On a train to San Francisco, Howard, Raj and Leonard fight for the affections of sci-fi star Summer Glau, while Sheldon is forced to turn to Penny for help when he leaves his flash drive behind.

Leonard, Sheldon, Howard and Raj are all taking a train trip to San Francisco to attend a symposium, at where the scheduled keynote speaker is Nobel Prize winning physicist Dr. George Smoot. Leonard, Howard and Raj, who all wanted to travel by plane instead, change their mind about taking the train when they see on board the beautiful Summer Glau, who they recognize from her role in Terminator: The Sarah Connor Chronicles (2008). Howard and Raj argue about who between the two has the right to hit on her, Raj who would need to take a trip to the bar car first. Meanwhile, Sheldon has forgotten an electronic file at the apartment he deems important for Dr. Smoot. After Leonard talks him out of getting off the train to go back to retrieve it, Sheldon decides on the slightly less abhorrent option of telephoning Penny to email it to him, which would entail Penny entering his (gasp) bedroom.—Huggo

The guys take a trip to a conference in San Francisco (Before that Howard opens the TiVo box to install a bigger hard drive, which voids the warranty.. Sheldon was reluctant to violate the sacred covenant between the manufacturer and the consumer that the warranty represents. The only other option was to erase season 1 of Battlestar Galactica which was also not acceptable to Sheldon) to meet guest speaker and 2006 Nobel Prize laureate Dr. George Smoot. Sheldon has forced them to take the train (takes 7 times as long and costs twice as much.. everyone voted to go by air, but Sheldon voted for the train and so everyone is now going by train). On the train, the guys notice Summer Glau of Terminator: The Sarah Connor Chronicles is on their car. Howard and Raj fight over who gets first shot at Summer. Raj is foreign and exotic, while Howard can talk to women without being drunk.

Howard ponders over how to approach Summer (It must be hot, since it is Summer).. Raj drinks a beer before being the first to approach her (he steals Howard's pick up line and swoops in before Howard makes his move), and they get on well (he regales Summer with his knowledge of the starts and the constellations) until Howard discovers Raj actually drank non-alcoholic beer, which apparently had a placebo effect, and points this out to Raj who thereupon reverts to his usual Selective Mutism.

Howard then takes over, but creeps Summer out with his awkward style (he talks about fart goblins and dreams where he tore Summer's legs off while dancing with her). Howard finally withdraws after Summer pointedly refuses to go out on a date with Howard, although she agrees for a selfie, but again refuses when Howard asks for a selfie which seems like they were making out Leonard finally gets his chance (after Summer rejects Howard), but Summer gets off the train before he can introduce himself.

Meanwhile, Sheldon realizes he forgot the USB flash drive with the paper he wants to show to Smoot, and needs extensive help from Penny to find it (she has to enter the apartment and enter Sheldon's room, which no one is allowed to enter) and email it to him. The flash drive is locked in Sheldon's drawer. The key is hidden in his room and people are not allowed to enter his room. Penny gets into Sheldon's room and finds the box where he had stored letters from his grandmother (his grandmother used to call him moon-pie). He calls his grandmother MeeMaw and she called him moon-pie as "he's Nummy Nummy and she could just eat him up" When she finally finds the box with the key, it turns out to be a Japanese puzzle box, but its made of light wood and Penny smashes it open instead of solving the puzzle as per Sheldon's instructions.

At the conference, however, Smoot is not impressed by Sheldon (he suggests that Smoot work on his research and publish under Cooper's name as the lead author), asking "With all due respect, Dr. Cooper, are you on crack?"

Title reference: Summer Glau and George Smoot's guest-starring on the show.