A Portland couple have two children with Pompe disease, a genetic anomaly that kills most before a child's tenth birthday. The husband, John, an advertising executive, contacts Robert Stonehill, a researcher in Nebraska who has done innovative research for an enzyme treatment. He has little money to fund his laboratory, and a thorny personality that drives away colleagues and funders. John and his wife Aileen raise money to help Stonehill's research and the required clinical trials. John takes on the task full time, working with venture capitalists and then rival teams of researchers. Time is running short, Stonehill's angry outburst hinder the company's faith in him, and the profit motive may upend John's hopes. The researchers race against time for the children who have the disease.Written by
In a bonus documentary on the DVD of the movie, producer Michael Shamberg talks about Harrison Ford's role as a scientist, Dr. Stonehill. Shamberg says, "He's rewritten the scientific language so it's completely accurate, and he will sound to real scientists like a real scientist. That's how methodical and serious an actor he is." See more »
When John Crowley first meets Dr. Stonehill in Nebraska, he said that the Dr. had hung up on him the day before yesterday, but goes on to say that his daughter had almost died last week. That is backwards from the earlier scenes, as the daughter was in the hospital after his call. See more »
[to a business friend who is trying to talk him out of quitting his job]
Hey, you're right! This is crazy. I'm chasing the wind. But I can't just sit around and wait for my kids to die.
See more »
Harrison Ford still displays great instincts both as an actor and as an executive producer. I believed in his character whole-heartedly, and convincingly-so as the movie unfolded the story. Brendan Fraser is also very convincing as a decent, but desperate and resourceful father. This is a movie that made me want to read the book, research the real issues.
I especially like the way the audience is increasingly drawn in, not only to the family seeking Dr. Stonehill's cutting edge medical research, but, moreover, in to the very lives of other families enduring a plight similar to the family of the main protagonists.
The movie is strong in terms of not over-playing the sentiment, which it would have been so easy to do.
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