Randall Batinkoff, Tambi Locke and Brady Smith co-star in the thriller, produced by RHI Entertainment in association with Larry Levinson Prods.
"Widow" revolves around journalist Melanie (Coppola) who suspects that her close friend Danny (Batinkoff), a millionaire real estate developer, has fallen for Olivia (Berkley), a woman who has married and murdered her previous husbands, including a software tycoon (Smith).
Locke will play a psychiatrist who introduces Olivia to Danny.
Armand Mastroianni is directing the film from a script by Riley Weston.
Coppola, who plays Mimi Clark on CBS' drama "Jericho", will next be seen on the big screen in Walt Disney Pictures' "National Treasure: Book of Secrets." She is repped by APA and Alan Iezman at Shelter Entertainment.
Locke, who co-starred on Fox's pilot "Born in the USA" this past development season, is repped by Stone Manners and Bob McGowan of McGowan Management.