In order to obtain all the world's money, Brain must reprogram a satellite orbiting the Earth. Luckily, NASA is offering the opportunity for one child to go on the next space shuttle mission. Pinky and The Brain have the enormous task of teaching Elmyra about the solar system in order for her to win the trip. ED BEGLEY, JR. guest stars as the voice of Lloyd Oldtire. A vicious cat prevents Pinky and The Brain from carrying out their world domination plans. To make the cat more obedient like a dog, Brain concocts a DNA cocktail, but the cat's personality is altered in a way the two mice didn't expect.