Elmyra takes Pinky and The Brain and several other pets to the veterinarian's office. When the doctor wants to publicize her bizarre cat/dog, Pussy Wussy, the mice must act to prevent discovery by The Circle. T'KEYAH CRYSTAL KEYMAH guest stars as the voice of Nurse Gland; FRED WILLARD guest stars as the voice of Doctor Glen Tarantella and DAVID PAYMER returns as the voice of Shad Equipo. Pinky and The Brain broadcast their world domination plans on a public access TV station. However, when network executives accidentally see the show, they decide to air it nationally. JACK CARTER guest stars as the voice of Ziff Twyman; JASON MARSDEN guest stars as the voices of Taylor Tyler Hoovie and Billy, and T'KEYAH CRYSTAL KEYMAH guest stars as the voices of Little Girl and Mother.