Masane Amaha and her daughter Rihoko are hiding from a government child protection organization as it want to take the girl. Masane is imprisoned for resisting the government and breaking the law. There she is attacked by the strange newest weapon that can turn into human. When she comes face to face with danger, her wrist begins to glow, and then she transforms into a powerful being. After defeating the enemy, Masane finds herself embroiled in a power struggle between influential organizations, and Masane herself is at the center of this conflict, because now she is the owner of the most destructive weapon on Earth - the Witchblade.