Driven is an episodic serial about a down and out limo driver in Miami, Tom Pope, who gets hired to drive the beautiful daughter of a super rich Miami developer to an insane asylum in Jackson, Mississippi. The girl, Holly will be kept drugged and looked after during the trip by a nurse who will accompany them. They are no more than half a day on the road when Holly palms her pills and gets into a fight with the nurse. During the struggle she throws the nurse out of the car at eighty miles an hour, killing her. Pope then finds himself stuck in the middle of nowhere with a dead body and a crazy girl, only the girl tells him she is sane, that she is being set up to be killed, and that he's now been set up to take the fall for it. Pope now has to find out the truth, while trying to stay alive at the same time.