Amy doesn't have time to work on super-asymmetry, so Sheldon goes to great lengths to ensure she's available to work with him even it if means accidentally sabotaging her career in the process. Also, Koothrappali ...
Sheldon won't tell anyone why he's never mentioned Tam, his childhood best friend, so Leonard takes matters into his own hands. Also, Bernadette and Penny take out Raj's fiancée, Anu, for dinner to get the skinny on her.
After Leonard tries to help Penny following a failed role on a TV show, she makes an important decision. Meanwhile, Raj and Stuart try to practice their social skills, and Sheldon navigates the intricacies of being funny.
Sheldon tries to relax after he is forced to take a vacation. Leonard struggles to be supportive of Penny after she quits her job. Amy receives unwanted attention from a co-worker. Bernadette seeks Stuart's help in replacing one of Howard's comic books.
When the guys can't get hold of any Comic-Con tickets, Sheldon tries to hold his own convention and ends up spending a wild night with James Earl Jones. Meanwhile, the girls try to feel more mature by going to a fancy hotel for tea.
Leonard's purchase of a dining room table causes Sheldon to reevaluate the changes in his life. Meanwhile, Howard is offered a chance to go back to space and Bernadette struggles with whether or not to encourage him.
After arguing with Sheldon, Howard tries to make amends by taking him to NASA headquarters in Houston. Penny has second thoughts about quitting her waitressing job when her car dies. Amy gets involved in trying to find Raj a date.
While Raj is wracked with guilt when he tries to date Lucy and Emily at the same time, Penny wrestles with whether to take a role in a cheesy movie and Sheldon is torn trying to choose between two gaming systems.
Penny gets fired from her movie and takes a serious look at her life. Raj sees Emily on a date with another man at the movies. Howard and Bernadette have to take care of his mother after she breaks her leg.
Sheldon gets upset about his career, the destruction of the comic book store and Leonard and Penny's future living arrangements. Howard and Bernadette struggle to keep hold of a caregiver for Mrs. Wolowitz.
Howard becomes nervous after NASA asks him to throw out the first pitch at a Los Angeles Angels game. Meanwhile, Leonard and Penny try to prove Sheldon wrong when he says that he and Amy have a 'superior' relationship.
Sheldon and Raj test whether they could survive a dark-matter research expedition in a salt mine by simulating the conditions in a steam tunnel. Meanwhile, Leonard and Penny seek advice from Howard and Bernadette when they argue about money.