Sheldon won't tell anyone why he's never mentioned Tam, his childhood best friend, so Leonard takes matters into his own hands. Also, Bernadette and Penny take out Raj's fiancée, Anu, for dinner to get the skinny on her.
Amy doesn't have time to work with Sheldon on super asymmetry, so he goes to great lengths to ensure she's available. Koothrappali doesn't want Wolowitz to join him in hosting a show at the planetarium.
Sheldon tries to bond with Amy's father, but when Wolowitz lures Mr. Fowler away with magic tricks, Sheldon has no choice but to bond with Mrs. Fowler. Also, Koothrappali and Anu try to get physical for the first time.
A VHS tape from Sheldon's past inspires him and Amy not to give up when they're still feeling down about their theory being disproven. Bernadette turns into a pageant mom when she tries to help Howard with his Magic Castle audition.
Sheldon and Amy are thrilled when their super asymmetry theory is proven by two physicists, until they try to kick Amy off the Nobel nomination. Bernadette gets one of her drugs approved and wants a reluctant Penny to head the sales team.