Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Cal Tech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with women. When Penny, a pretty woman and an aspiring actress from Omaha, moves into the apartment across the hall from Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend.
When beauty meets the brains.
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Did You Know?
, who plays the Neuroscientist Amy Fowler, is a Neuroscientist in real-life. See more
A line of the opening song states 'Neanderthals developed tools'. Homo habilis actually developed tools long before the Neanderthals. See more
So, what do you say Sheldon, are we your X-Men?
No. The X-Men were named after the X in Charles Xavier. Since I am Sheldon Cooper, you will be my C-Men.
[as Sheldon walks away
Oh, that's not a good name.
One of the final cards to appear in the credit sequence is the vanity card for Chuck Lorre Productions. In keeping with his practice on "Dharma and Greg" and "Two and a Half Men", there is a different message on the card each week, written by Chuck Lorre himself. See more
Referenced in Welshy Reviews: Psychoville
History of Everything (The Big Bang Theory Theme)
Music & lyrics by Barenaked Ladies
Performed by Barenaked Ladies
Played during the opening titles See more