Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Cal Tech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with women. When Penny, a pretty woman and an aspiring actress from Omaha, moves into the apartment across the hall from Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend.
When beauty meets the brains.
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Did You Know?
Out of the main male cast members, Howard (Simon Helberg
) is the only one who hasn't seen Penny (Kaley Cuoco
) naked in person, despite being the first to flirt with her. See more
Sheldon's trademark knock (3 knocks + name, 3 knocks + name, 3 knocks + name) was not established until later in the first season, however, in a scene that pre-dates the start of the show, he is shown doing that knock sequence. See more
[to a random person
I'm gonna be in People magazine!
[turns around to him
Call me when you're on the cover.
One of the final cards to appear in the credit sequence is the vanity card for Chuck Lorre Productions. In keeping with his practice on "Dharma and Greg" and "Two and a Half Men", there is a different message on the card each week, written by Chuck Lorre himself. See more
History of Everything (Instrumental)
Composed by Barenaked Ladies
Performed by Barenaked Ladies
Played during the end credits See more