Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Cal Tech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with women. When Penny, a pretty woman and an aspiring actress from Omaha, moves into the apartment across the hall from Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend.
When beauty meets the brains.
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Did You Know?
As the series progressed, each taping of the show was attended by Caltech students. See more
When Sheldon explains why he likes the spot he sits in, one thing is because he's right in a cross breeze created by the window behind them (the one we always see), and another window located off-screen (but based on where he points is somewhere behind where their workstations are, and to the left of the door). This would be impossible as either wall that window would be in would look out into the hallway or into the neighboring apartment. Furthermore, considering there is no screen on the window, it is highly unlikely Sheldon would, or would ever let Leonard or anyone else, open the window simply for air, considering it would risk allowing a bird (or any insects) to fly in, because of Sheldon's fear of birds and of anything that could spread diseases. See more
[repeated line when Sheldon tells a sarcastic joke
One of the final cards to appear in the credit sequence is the vanity card for Chuck Lorre Productions. In keeping with his practice on "Dharma and Greg" and "Two and a Half Men", there is a different message on the card each week, written by Chuck Lorre himself. See more
Featured in Dear Mr. Watterson
History of Everything (Instrumental)
Composed by Barenaked Ladies
Performed by Barenaked Ladies
Played during the end credits See more