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Title: John C. Reilly/My Chemical Romance (21 Oct 2006)
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| Episode cast overview: | |||
| Fred Armisen | ... | Various | |
| Will Forte | ... | Various / George W. Bush | |
| Bill Hader | ... | Various | |
| Darrell Hammond | ... | Various / Brit Hume | |
| Seth Meyers | ... | Weekend Update Anchor | |
| Amy Poehler | ... | Various / Weekend Update Anchor / Kim Jong Il | |
| Maya Rudolph | ... | Various | |
| Andy Samberg | ... | Various / Aaron Carter | |
| Jason Sudeikis | ... | Various / A-Hole / Nick Carter | |
| Kenan Thompson | ... | Various / Flavor Flav | |
| Kristen Wiig | ... | Various / A-Hole | |
| My Chemical Romance | ... | Themselves - Musical Guest | |
| John C. Reilly | ... | Self - Host | |
Sketches include a Brit Hume interview with President Bush, John's musical monologue with Will Ferrell as James Lipton, John as a racist employee at Colonial Williamsburg, a parody of "House of Carters", 2 A-holes meeting a personal trainer and John (in a speedo) teaching Will Forte (also in a speedo) the fundamentals of swimming. Special Report with Brit Hume (Darrell Hammond, Will Forte), Monologue (John C. Reilly, Will Ferrell), Colonial Williamsburg (John C. Reilly, Jason Sudeikis), Swim Instructor (John C. Reilly, Will Forte), A-Holes Workout (John C. Reilly, Jason Sudeikis, Kristen Wiig), Weekend Update (including Kenan as Flavor Flav) (Seth Meyers, Amy Poehler), Crying (John C. Reilly, Maya Rudolph, Amy Poehler, Kristen Wiig), Oreo Cookies #1 (John C. Reilly, Andy Samberg), House of Carters Promo (Jason Sudeikis, Andy Samberg, Kenan Thompson), Harpoon Man: An SNL Digital Short (John C. Reilly, Andy Samberg), Oreo Cookies #2 (John C. Reilly, Kenan Thompson), Bearshark (John C. ... Written by Anonymous
