From what I know, in the game, Tak is trying to save his village from an evil shaman. The villain from the games has only a minor role in the actual cartoon series. The characters from the game act like they did with Lok's false heroism and Tak's wise-cracking nuttiness, but then Nick threw in some new characters for some reason that REALLY don't help the series much.
I was expecting a show that followed the games and their story lines, since the game and the show share the same title, but instead, I got a series made up of Tak's misadventures, like a Saturday morning cartoon. Also, though the title says "And the Power of Juju", the Jujus in the show appear rarely in the episodes, like 1 out of every 6 episodes.
If you liked the games, then you'd might get a kick out of this show, but for a person who never played the game, yet knew the basic storyline, I was really let down. You might say "But the Sonic the Hedgehog cartoons didn't follow any game story lines neither." But at least they had a long-branching storyline to them, with Sonic trying to beat Robotnik, but in "Tak"s case, Nick obviously thought making Tak a Ed-Edd-N-Eddy-esqe TV series would be more pleasing to audiences. It sure wasn't for me. Like the game's ratings, this show sucked. Nickelodeon, stick to "Avatar: The Last Airbender", because that is the only true great show you have.