During Derek Reese's flashback scene in the future, we learn that Andy Goode was so ashamed of his involvement in creating Skynet that he began using the alias William "Billy" Wisher. William Wisher is a long-time collaborator of James Cameron, the creator/director of the Terminator films. Wisher also co-wrote the screenplay for Terminator 2: Judgment Day (1991).
Thomas Dekker portrayed a character on Heroes (2006) who was originally scripted to come out as gay. Dekker's agent demanded the script be changed so as to not jeopardise Dekker's chances of landing the role of John Connor.
The character of Charlie Dixon was played by Tim Guinee in the original pilot. His scenes were re-shot with Dean Winters before the show aired in early in 2008 and Dean Winters played the character throughout the series.
Sarah and John are both blamed for the death of Doctor Miles Bennett Dyson, the inventor of the neural-net processor that led to the development of Skynet. In "Terminator 2: Judgement Day", Miles Dyson was fatally shot by multiple SWAT team officers and succumbed to his bullet wounds and detonated a bomb that destroyed Cyberdyne headquarters, when he remained behind to allow Sarah, John and the T101 to escape.
2 years after the series ended, Lena Headey was cast as antagonist Cersei Lannister in the groundbreaking HBO series Game of Thrones (2011) (TV series). Emilia Clarke whom plays Daenerys Targaryen in the HBO series went on to play Sarah Connor in Terminator Genisys (2015).
In a scene that was cut from the pilot (#1.1) Sarah tells Cameron about a recurring dream she had about protecting John, but dies every time and cries talking about, when Cameron removes a bullets from Sarah's torso.
Guest star Craig Fairbrass had starred in a sci-fi film called Galaxis (1995) which had been described as a critic as "Star Wars meets The Terminator". In the film Brigitte Nielsen starred as an intergalactic warrior princess whom teleports to Earth as she sets out to stop an evil warrior from possessing a magic crystal which will make him all powerful. Brigitte Nielsen had starred opposite Arnold "The Terminator" Schwarzenegger in Red Sonja (1985).
14 years before the series first aired on American television, Thomas Dekker had a small role as one of Captain Jean-Luc Picard's children in Star Trek Generations (1994). In the sequel Star Trek: First Contact (1996) Captain Picard and the Enterprise crew travel back in time to Post World War III April 4th 2063 as they set out to stop the evil cyborg creatures The Borg from preventing alcoholic rocket scientist Zefram Cochrane from piloting his warp ship and making first contact with extra terrestrials which will alter the timeline and prevent the formation of the United Federation of Planets.
Not the first time Shirley Manson has played a robot. In the music video of "The World is Not Enough" by Garbage, she played a robot replica of herself whom the real Shirley Manson killed and took her place. In the series, Catherine Weaver (Manson), a T-1001 liquid metal Terminator, replaced the real Catherine Weaver, the CEO of Zeira Corporation.
In the narrative behind why Jesse killed Riley in Terminator: The Sarah Connor Chronicles: Today is the Day - Part 1 (2009), which is revealed that she had planned right from the start and frame Cameron for Riley's murder, so she could destroy John's trust with Cameron. Jesse had a deep hatred of Cameron and had lost all respect for John because he recruited machines and she had it her personal mission to destroy the trust and relationship between John and Cameron and she brought Riley Dawson with her from the future and used her as the tool to achieve her scheme.
In the pilot, Cameron states that she comes from the year 2027. Both Kyle Reese, the T800, The T1000 and the T101 came from the year 2029, which was established in The Terminator (1984) and Terminator 2: Judgment Day (1991). It is obvious that Cameron was sent back through time to 1999 by John Connor and the Human Resistance 2 years before Kyle Reese, the T800, the T1000 and the T101 were sent back through time.
At the end of the series, John Henry removes Cameron's CPU and travels to the future. If the series hadn't been canceled and if there had been a 3rd and 4th season. It's likely in the alternate future war, John finds John Henry and gets back Cameron's CPU. However another version of Cameron from that timeline is programmed to kill John, but fails. Instead of destroying Cameron, John removes that version of Cameron's CPU and replaces it with the one that John Henry removed from the original Cameron which Cameron reactivates and now that she has a new Terminator Endoskeleton, Cameron continues to act as John's bodyguard and willingly aids the Human Resistance against Skynet.