Christina's swag lottery, with the Mode closet clothes and accessories, creates a feeding frenzy among the office fashionistas, while Betty wears herself out helping Daniel who had his credit card cut off, because of a $20,000 expense report that Betty filled and who was rejected, making it impossible for him to wine and dine an important Japanese designer, Oshi.
Sophia Reyes rules Daniel Meade's heart masterly, soon getting him to propose to her and is even accepted as bride by his parents, who like her. Meanwhile as Betty's new boss, Sophia orders her to replace a suddenly prohibited lead article in her new feminist magazine by one on the social experiences of her, common ugly bird, working in Daniel's fancy fashion magazine, so she goes back there interviewing everybody. Betty finds out that Sophia not only enjoyed the services of hunky exotic dancer and much more Hunter 9 herself regularly but actually hired him on a ...
Wilhelmina, with Mark as her right hand, plans who's to stay and who'll be kicked out when she once takes over Daniel's position. Daniel returns to the office after 14 days licking wounds. He immediately rehires Betty as assistant. Hilda has success in delivering her father's cakes and chooses to start a new business without telling him about it before taking in orders.
Betty has her job cut out preparing for Mode's huge New York City's Fashion Week event. Marc and Amanda can't delay getting their hands on something everybody desires, Christina wishes to create her mark in the design world and Daniel calls for Hilda to help her sister. Alexis makes her entrance!
Alexis' shocking announcement causes great commotion at both Mode and the Meade home. Betty tries to maintain the peace and order at Mode, however, she is about to face her own personal turmoil when Henry asks her out on a date and Walter tells her he's got a big surprise in store - he has been offered a promotion in Maryland. Meanwhile, Whilhelmina plots her next move to conquer Mode and Justin gets sent home from school for fighting.
Daniel reconnects with New York City's top lawyer Grace Chin, which he once stood up for a date in college. Betty befriends Charlie, an out-of-towner she meets at the Mode cafeteria but later discovers to be Henry's girlfriend.
Daniel keeps secret from Alexis the fact that he is the one who hired Grace to defend their father, something which Wilhelmina uses to bring the siblings apart. Meanwhile, when invited by Henry to Charlie's birthday party, a desperate Betty asks Dr. Farkas, her orthodontist, to be her date. Finally, Amanda catches the eye of an unusual designer who claims that she is his muse.
Betty is in for some wild drama when Marc's mother, Jean Weiner, stops by Mode, given that the latter doesn't seem to know that her son is gay and Betty acts as his girlfriend to help him keep his secret. Meanwhile, Daniel and Alexis are forced to work together when Claire names them both co-editors-in-chief.
Daniel tells Betty to quit stalking him when she tries to protect him from unauthorized biographer Quincy Combs. Later, Daniel is appalled when he is told his latest bedmate was underage - by her mother.
At a medieval-themed restaurant where Mode assistants celebrate Secretaries' -- er, Administrative Assistants' Day, Henry battles to defend Betty's honor (which leaves girlfriend Charlie less than thrilled). Betty convinces Daniel that he has a sex addiction and needs help.
When Ignacio is forced to leave the U.S. to apply for legal immigration, his daughters and Justin accompany him to Mexico, where Betty becomes obsessed with finding her mother's mother. At Mode, Daniel and Alexis fight over using Jordan Dunn as their featured real-world adventurer, as she was once Alex' girlfriend.
The season-end cliffhanger: Justin is thrilled with the boy playing Tony in the school play falls mysteriously ill and he is promoted from understudy. Santos finds trouble when he stops at a store to buy Justin a good-luck present. Alexis finds an unpleasant surprise when she takes their father's car to rush Daniel to the hospital for an overdose.
After so many sad events in Betty's life, she can't seem to get her life into perspective. She denies that she is wrecked by the fact that Henry is leaving. Amanda on the other hand is shocked after discovering who her real mother is. Of course, Wilhelmina is right around the corner arranging to take advantage of everything going on around her.
Daniel and Alexis remain in the hospital following their car accident. Betty must break into Wilhelmina's apartment to get 'The Book' for Daniel to review. Betty and Christina are almost caught in the apartment when Wilhelmina and her bodyguard come home for lunchtime tryst. When Wilhelmina discovers that Betty knows she offers Betty help in getting Ignacio home in return for Betty's silence. Meanwhile, Hilda and Justin deal with Santos death and Mark and Amanda deal with Halston, Amanada's legacy.
Betty tries to avoid thinking about her problems with boyfriend Henry and focuses on helping Daniel in the annual Mode benefit event but suddenly encounters the new sandwich cart employee, Gio, who both fascinates her and challenges her to follow her dreams. Henry has to face ex-girlfriend Charlie after finding shocking news about her pregnancy. Wilhelmina finds new ways to drag Alexis back to her side. Ignacio is in Mexico facing a deadly threat from his past while Marc and Amanda plan new ways to publicly promote Amanda as Fey Sommer's daughter.
A prospective major advertiser threatens to leave Mode unless Daniel fires his transsexual sister Alexis. Meanwhile, Betty reads another writer's story in her creative writing class and things spin out of control. Justin goes through a rebellious stage failing an algebra test and making out with girls.
Betty tries Internet dating but Henry gets jealous and shows up at the bowling alley. Meanwhile Alexis' memory returns when she and Daniel have dinner with Bradford and Wilhelmina. Back in Queens, Hilda joins the widow set until Justin gets arrested. While in Manhattan Marc has to choose between chunky and hunky when he gets dates with a buff underwear model and the film buff photographer who's shooting him.
Daniel happens to attend the musical Wicked where Henry and Betty are having a date, as he brings a date of his own, a potential advertiser for his magazine. Betty tries to hide the fact that she is dating Henry by pretending that Gio is her boyfriend. Justin finds out about his mother Hilda's new unconventional job. Marc and new boyfriend, Cliff, have to face problems of their own.
Ignacio is slated to become a citizen but Betty may not attend the ceremony because she and her Dad have fallen out over Betty's dating Henry. Meanwhile Daniel tries to stop his father's wedding after discovering that Wilhelmina has been cheating with her bodyguard. Wilhelmina is worried that her maid of honor Posh Spice might steal her spotlight. Marc and new boyfriend, Cliff, have problems of their own.
Unable to decide who their father left in charge of the Meade Empire, Daniel and Alexis settle the matter with a paint ball fight inside MODE offices. Trying to spice her love life, Betty drags Henry into a double date with romantic assertive Gio and her very outgoing sister, Hilda, at a lively reggaeton club. Wilhelmina faces financial problems in new launched Slater Magazine and tries to improve her public image ending in a total media disaster as she ran over Betty White by mistake. Amanda and Nick finally settle their differences.