Even if Niko kills Luis during "Three Leaf Clover", he will still appear during the diamond exchange cutscene in "Museum Piece".
In "No Way on the Subway", Jim looks and sounds completely different than his appearance in the Lost and Damned.
In the cutscene for the mission 'Museum Piece', Niko enters through a swinging door. However the behaviour of this door changes throughout the cutscene. When Niko attempts to leave, Ray is able to slam it closed, and at the end of the cutscene the door is able to stay in the one position to allow us a view of Ray after Niko leaves.
In Ilyena's random character cutscene, she states that she and her daughter live in a one room apartment. But if Niko kills Anna's boyfriend, Ilyena will say that Anna is upstairs crying.
In the mission "Deconstruction for Beginners" the workers are on strike with armed guards watching over the site to prevent scabs from working, construction noises can clearly be heard.
In the mission 'Clean Getaway' for Vlad Glebov, the subway train stops at an abandoned station at Dukes Boulevard. No other train ever stops here.
In the mission "Flatline", a character is on a life support machine, as is stated when you attempt to turn it off. However, the character is well able to speak, something which would be highly unlikely if his condition necessitated the machine.
When traveling down Babbage Drive in Central Alderney, it is a 4-lane road, like a highway, and there is the north and south bound lanes. Like a highway, the north and south bound lanes have two lanes each. When looking at either highway lane, it has the double solid yellow line, which would mean that the northbound and southbound lanes are in fact, a two-way road, and that Babbage drive is in fact, two different roads.
On the radio you can hear Lazlow say "you get in high-speed
accidents, you go "dude, I lost my right arm" and your friends would say "dude,
who cares? you can drum."" This is clearly a reference to Rick Allen, but Rick Allen lost his left arm, not the right.
If the player receives a two star wanted level, police officers start to use the Pump Shotgun. Strangely, if the player gets into a police car they receive the Combat Shotgun.
The first overhead roadway sign that appears after Dukes Boulevard becomes Broker-Dukes Expressway has the visible spelling mistake of "airport" spelled as "aiport", on the same sign for the Meadows Park and Meadow Hills landmarks.
In the mission "Waste Not Want Knots" cutscene, associate Gordon Sargent is noted as holding the assault rifle in a left-handed position during the entire cutscene including to the end scene fragment, but this is the only time this occurs as all other instances are right-handed positions and especially when compared to the following "Three Leaf Clover" mission cutscenes. Considering this is the only instance, it is never explained whether there was ever an intended change in which position was always intended or if this was a motion capture mirror image reversal.
The CJ's Mini Market convenience store "accessories" product notation at the Bridger-Manzano intersection in Leftwood, Alderney is either unknowingly misspelled as assessories, or this is an intended wordplay instead of the actual word but this appears to be a spelling-related mistake considering there is no specific illusion for intended puns on it.
The American Travel Guide website states in mentioning "Brussels" as being in France, though it is in Belgium, but this is not an ordinary mistake but instead an intentional one considering the separated differences of a non-European distinguishing certain cities from a totally different country. This is something designer Obbe Vermeij noted as being part of the overall website's humor as intended.
In one of the boating activities you go on with Brucie, he tells you to go to the "Statue of Freedom" and the subtitles read "Statue of Happiness", which is what it is actually called in the game.
One of the signs at the airport says "Car park", which is a UK term. In the U.S., they are referred to as parking garages or parking lots.
Storefronts in Alderney City sport 669 area codes, which is for California.
Liberty City's transportation agency is called the "Liberty Transport Authority", which is British parlance. In U.S. lexicon, it would be called the "Liberty Transit Authority".
In the mission 'Hating the Haters' Bernie says he has been getting attacked at the park and needs the help of a good fighter like Niko, but if you get into a fight with someone before you reach the park during the mission, Bernie will also start to fight the pedestrian and he fights just as well as Niko. While fighting, he will also speak with a different style of voice.
Niko got The Triangle strip club back to Dwayne in the mission Undress To Kill, but later when the two hang out and enter this club (if the player chooses to) it is not even mentioned.
If you hang out with Dwayne long enough, he will eventually tell you that he doesn't know how to read or write well. However, he is perfectly capable of sending text messages with proper spelling and word use.
One of the Mafia crime families is named the Ancelottis. The Italian pronunciation would be 'AnCHelottis'; despite this, most of the Italian characters mispronounce the name, besides Niko and others.
In "She's A Keeper", while Gordon is moving Grace Ancelotti from the safe house to the trunk of the car, he yells out that Grace bit him. How could Grace bite Gordon when her mouth is gagged, her hands are tied behind her back (so she can't grab him to bite him), his hands are on her waist and he's behind her the whole time?
Niko pronounces his surname BelliCH, but if he starts dating Kiki Jenkins, on the first date he pronounces is BelliK upon introducing himself.
Mikhail Faustin's accent sounds nothing like the other Russian characters, as his voice actor Karel Roden is from Czech Republic, and his Czech accent is very different from Russian.